Rol del Enterococcus faecalis en las infecciones endodonticas persistentes
DOI:
https://doi.org/10.62305/biosana.v6i3.1073Palabras clave:
Enterococcus faecalis; biopelículas; infecciones endodónticas; tratamiento de conductos radiculares; fracaso del tratamiento endodónticoResumen
Las infecciones endodónticas persistentes son un problema clínico importante debido a la complejidad del sistema de conductos radiculares y a la capacidad de ciertos microorganismos para sobrevivir las diferentes terapias antimicrobianas. El Enterococcus faecalis ha sido identificado como uno de los principales patógenos asociados al fracaso del tratamiento endodóntico, especialmente en casos de retratamiento. La presente revisión narrativa se planteó como objetivo analizar la evidencia científica más actualizada sobre el papel de Enterococcus faecalis en las infecciones endodónticas persistentes, profundizando en sus mecanismos de virulencia, de resistencia e implicaciones clínicas. Se realizó una búsqueda en bases de datos como PubMed, Scopus, SciELO y LILACS, se seleccionaron en su mayoría estudios relevantes publicados en los últimos años. La evidencia analizada indicó que la formación de biopelículas constituye un factor clave en la persistencia bacteriana, al proporcionar protección frente a agentes antimicrobianos y facilitar la colonización de los túbulos dentinarios. Asimismo, se identificaron limitaciones en los protocolos convencionales de desinfección, así como las estrategias terapéuticas actuales orientadas a la disrupción del biofilm. En conclusión, esta bacteria desempeña un papel determinante en el fracaso endodóntico, lo que resalta la necesidad de plantear enfoques terapéuticos más efectivos e integrales.
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Stuart CH, Schwartz SA, Beeson TJ, Owatz CB. Enterococcus faecalis: Its role in root canal treatment failure and current concepts in retreatment. Journal of Endodontics. 2006;32(2):93-8. Located at: Scopus. doi:10.1016/j.joen.2005.10.049
Barbosa-Ribeiro M, Gomes BPFA, Arruda-Vasconcelos R, Monteiro IDA, Costa MJF, Sette-de-Souza PH. Antibiotic Resistance Profile of Clinical Strains of Enterococci from Secondary/Persistent Endodontic Infections: What do We Know? A Systematic Review of Clinical Studies. Journal of Endodontics. 2024;50(3):299-309. Located at: Scopus. doi:10.1016/j.joen.2023.12.007
Neelakantan P, Romero M, Vera J, Daood U, Khan AU, Yan A, et al. Biofilms in endodontics—current status and future directions. International journal of molecular sciences [Internet]. 2017 [citado 16 de marzo de 2026];18(8):1748. Disponible en: https://www.mdpi.com/1422-0067/18/8/1748
He Q, Hou Q, Wang Y, Li J, Li W, Kwok LY, et al. Comparative genomic analysis of Enterococcus faecalis: Insights into their environmental adaptations. BMC Genomics. 2018;19(1). doi:10.1186/s12864-018-4887-3
Nappi F, Avtaar Singh SS, Jitendra V, Fiore A. Bridging Molecular and Clinical Sciences to Achieve the Best Treatment of Enterococcus faecalis Endocarditis. Microorganisms. octubre de 2023;11(10):2604. doi:10.3390/microorganisms11102604
Schwartzman JA, Lebreton F, Salamzade R, Shea T, Martin MJ, Schaufler K, et al. Global diversity of enterococci and description of 18 previously unknown species. Proc Natl Acad Sci U S A. 2024;121(10). doi:10.1073/pnas.2310852121
Sharma J, Jhamb S, Mehta M, Bhushan J, Bhardwaj SB, Kaur A. Characterization of Enterococcus faecalis associated with root canal failures: Virulence and resistance profile. Journal of Conservative Dentistry and Endodontics. 2025;28(7):602-6. Located at: Scopus. doi:10.4103/JCDE.JCDE_190_25
Boreak N, Mowkly AAM, Sharwani A, Almasoudi SA, Huraysi A, Sulily IA, et al. Genomic insights into Enterococcus faecalis implicated in endodontic infections: resistance, virulence, and genetic variability. Cellular and Molecular Biology. 2025;71(1):102-10. Located at: Scopus. doi:10.14715/cmb/2025.70.1.11
Barbosa J, Borges S, Teixeira P. Virulence factors of enterococcus faecalis: The promoters for their pathogenicity. En: Mack HL, editor. Enterococcus Faecalis: Molecular Characteristics, Role in Nosocomial Infections and Antibacterial Effects. Nova Science Publishers, Inc.; 2014. p. 1-17.
Beyth N, Poraduso-Cohen R, Hazan R. Enterococcus faecalis in dental infections: Virulence factors, molecular characteristics, antibacterial and anti-infective techniques. En: Enterococcus Faecalis: Molecular Characteristics, Role in Nosocomial Infections and Antibacterial Effects [Internet]. 2014. p. 137-64. Located at: Scopus. Disponible en: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84956721124&partnerID=40&md5=deba4699454a8afb6c1847339cd0a839
Preethee T, Kandaswamy D, Hannah R. Molecular identification of an Enterococcus faecalis endocarditis antigen efaA in root canals of therapy-resistant endodontic infections. J Conserv Dent. 2012;15(4):319-22. doi:10.4103/0972-0707.101886
Karygianni L, Ren Z, Koo H, Thurnheer T. Biofilm matrixome: extracellular components in structured microbial communities. Trends in microbiology [Internet]. 2020 [citado 18 de marzo de 2026];28(8):668-81. Disponible en: https://www.cell.com/trends/microbiology/fulltext/S0966-842X(20)30087-1
Flemming HC, Wuertz S. Bacteria and archaea on Earth and their abundance in biofilms. Nature Reviews Microbiology [Internet]. 2019 [citado 18 de marzo de 2026];17(4):247-60. Disponible en: https://www.nature.com/articles/s41579-019-0158-9
Wu B, Zhou Z, Hong X, Xu Z, Xu Y, He Y, et al. Novel approaches on root canal disinfection methods against E. faecalis. J Oral Microbiol. 2025;17(1). doi:10.1080/20002297.2025.2475947
Saber SEDM, El-Hady SA. Development of an intracanal mature Enterococcus faecalis biofilm and its susceptibility to some antimicrobial intracanal medications; An in vitro study. Eur J Dent. 2012;6(1):43-50.
Rôças IN, Siqueira JF, Santos KRN. Association of Enterococcus faecalis with different forms of periradicular diseases. J Endod. 2004;30(5):315-20. doi:10.1097/00004770-200405000-00004
Yang S, Meng X, Zhen Y, Baima Q, Wang Y, Jiang X, et al. Strategies and mechanisms targeting Enterococcus faecalis biofilms associated with endodontic infections: a comprehensive review. Frontiers in Cellular and Infection Microbiology. 2024;14. Located at: Scopus. doi:10.3389/fcimb.2024.1433313
Usri K, Prisinda D, Malinda Y. Analysis of Various Factors that Cause the Failure of Root Canal Treatment: Scoping Review. J Int Dent Med Res. 2023;16(1):404-10.
Anuradha B, Sharumathi R, Venkatesh A, Niveditha S. Endodontic treatment failures and its management―a review. Indian J Public Health Res Dev. 2019;10(11):3049-53. doi:10.5958/0976-5506.2019.04374.2
Jaramillo DE. Irrigation of the Root Canal System by Laser Activation (LAI): PIPS Photon-Induced Photoacoustic Streaming. En: Basrani B, editor. Endodontic Irrigation: Chemical Disinfection of the Root Canal System. Springer International Publishing; 2015. p. 227-35. doi:10.1007/978-3-319-16456-4_13
Berutti E, Castellucci A. Nonsurgical Root Canal Retreatment. En: Peters OA, editor. The Guidebook to Molar Endodontics. Springer Berlin Heidelberg; 2016. p. 233-68. doi:10.1007/9783662529010_9
Ghazal T, Ahmed MA, Qazi FUR, Haider MM, Naeem S, Jouhar R, et al. Mutational analysis of cytoplasmic domain of integrin subunit alpha-1 and its association with periapical wound healing after surgical endodontic treatment. PLoS ONE. 2024;19(10 October). doi:10.1371/journal.pone.0303627
Lima SM de F, de Pádua GM, Sousa MG da C, Freire M de S, Franco OL, Rezende TMB. Antimicrobial peptide-based treatment for endodontic infections - Biotechnological innovation in endodontics. Biotechnol Adv. 2015;33(1):203-13. doi:10.1016/j.biotechadv.2014.10.013
Celikel P, Ceyhan B, Buyuksefil M, Levchenko A, Sengul F, Derelioglu SS, et al. Antimicrobial activity of different irrigation solutions on Enterococcus faecalis in the root canal of the primary teeth—an in vitro comparative study. J Clin Pediatr Dent. 2025;49(4):148-53. doi:10.22514/jocpd.2025.085
Singh N, Shenvi S, Praveen A, Khaitan A, Kumar SB, Jadhav KR, et al. Antibacterial Efficacy of N-Acetyl Cysteine Combined with Two Photodynamic Therapy Protocols Against Enterococcus faecalis in Infected Root Canals: An In Vitro Study. G Ital Endodonzia. 2025;39(3):31-9. doi:10.32067/GIE.2025.536
Tonini R, Salvadori M, Audino E, Sauro S, Garo ML, Salgarello S. Irrigating solutions and activation methods used in clinical endodontics: a systematic review. Frontiers in oral health [Internet]. 2022 [citado 26 de marzo de 2026];3:838043. Disponible en: https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2022.838043/full
Gomes BP, Aveiro E, Kishen A. Irrigants and irrigation activation systems in endodontics. Brazilian dental journal [Internet]. 2023 [citado 26 de marzo de 2026];34:1-33. Disponible en: https://www.scielo.br/j/bdj/a/xg835S3btBPdnS3BgCSTHzD/?format=html&lang=en
Shrestha A, Kishen A. Antibiofilm efficacy of photosensitizer-functionalized bioactive nanoparticles on multispecies biofilm. Journal of Endodontics [Internet]. 2014 [citado 26 de marzo de 2026];40(10):1604-10. Disponible en: https://www.sciencedirect.com/science/article/pii/S0099239914003045
Paganelli FL, Willems RJ, Leavis HL. Optimizing future treatment of enterococcal infections: Attacking the biofilm? Trends Microbiol. 2012;20(1):40-9. doi:10.1016/j.tim.2011.11.001
Herrera-Hidalgo L, Fernández-Rubio B, Luque-Márquez R, López-Cortés LE, Gil-Navarro MV, de Alarcón A. Treatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge. Antibiotics. 2023;12(4). doi:10.3390/antibiotics12040704
Caballero Gómez N, Manetsberger J, Lavilla Lerma L, Martínez Martos JM, Benomar N, Abriouel H. Exploring synergistic effects of essential oils compounds with antibiotics and biocides against multidrug-resistant foodborne pathogens. Appl Food Res. 2024;4(2). doi:10.1016/j.afres.2024.100581
Sena G, De Rose E, Crudo M, Filippelli G, Passarino G, Bellizzi D, et al. Essential Oils from Southern Italian Aromatic Plants Synergize with Antibiotics against Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecalis Cell Growth and Biofilm Formation. Antibiotics. 2024;13(7). doi:10.3390/antibiotics13070605
Vadakkan K, Ghodake GS, Lai CW, Vijayanand S, Hemapriya J. A critical review on innovative targets for signal disruption in Enterococcus faecalis infection management. Microb Pathog. 2025;207. doi:10.1016/j.micpath.2025.107876
Hongsing P, Ngamwongsatit N, Kongart C, Nuiden N, Phairoh K, Wannigama DL. Cannabidiol Demonstrates Remarkable Efficacy in Treating Multidrug-Resistant Enterococcus Faecalis Infections In Vitro and In Vivo. Trends Sci. 2024;21(9). doi:10.48048/tis.2024.8150
Sewid AH, Sharaf M, El-Demerdash AS, Ragab SM, Al-Otibi FO, Taha Yassin M, et al. Hexagonal zinc oxide nanoparticles: a novel approach to combat multidrug-resistant Enterococcus faecalis biofilms in feline urinary tract infections. Front Cell Infect Microbiol. 2024;14. doi:10.3389/fcimb.2024.1505469
Ali IAA, Matinlinna JP, Lévesque CM, Neelakantan P. Trans-cinnamaldehyde attenuates enterococcus faecalis virulence and inhibits biofilm formation. Antibiotics. 2021;10(6). doi:10.3390/antibiotics10060702
Wu B, Zhou Z, Hong X, Xu Z, Xu Y, He Y, et al. Novel approaches on root canal disinfection methods against E. faecalis. J Oral Microbiol. 2025;17(1). doi:10.1080/20002297.2025.2475947
Schuenck-Rodrigues RA, de Oliveira de Siqueira LB, dos Santos Matos AP, da Costa SP, da Silva Cardoso V, Vermelho AB, et al. Development, characterization and photobiological activity of nanoemulsion containing zinc phthalocyanine for oral infections treatment. J Photochem Photobiol B Biol. 2020;211. doi:10.1016/j.jphotobiol.2020.112010
Chen J, Zhang H, Zhao T, Yu Y, Song J, Zhao Y, et al. Oxygen Self-Supplied Nanoplatform for Enhanced Photodynamic Therapy against Enterococcus Faecalis within Root Canals. Adv Healthc Mater. 2024;13(13). doi:10.1002/adhm.202302926
Sahu M, Singh SK, Singh M, Shukla A, Nath G. Bacteriophage therapy a promising alternative treatment approach for infections caused by multidrug-resistant (MDR) Enterococcus species. Microbe. 2025;8. doi:10.1016/j.microb.2025.100534
Song M, Wu D, Hu Y, Luo H, Li G. Characterization of an Enterococcus faecalis Bacteriophage vB_EfaM_LG1 and Its Synergistic Effect With Antibiotic. Front Cell Infect Microbiol. 2021;11. doi:10.3389/fcimb.2021.698807
Vishwakarma RK, Yadav BS, Gautam P, Sahu M, Singh A, Kumar A, et al. In-vitro analysis of biofilm formation and synergistic antibiotic-phage therapy for amoxicillin-resistant Escherichia coli. Arch Microbiol. 2025;207(12). doi:10.1007/s00203-025-04542-6
Grygorcewicz B, Gliźniewicz M, Olszewska P, Miłek D, Czajkowski A, Serwin N, et al. Response Surface Methodology Application for Bacteriophage–Antibiotic Antibiofilm Activity Optimization. Microorg. 2023;11(9). doi:10.3390/microorganisms11092352
Tatta ER, Paul S, Kumavath R. Transcriptome analysis revealed the synergism of novel rhodethrin inhibition on biofilm architecture, antibiotic resistance and quorum sensing in Enterococcus faecalis. Gene. 2023;871. doi:10.1016/j.gene.2023.147436
McBrayer DN, Cameron CD, Gantman BK, Tal-Gan Y. Rational Design of Potent Activators and Inhibitors of the Enterococcus faecalis Fsr Quorum Sensing Circuit. ACS Chem Biol. 2018;13(9):2673-81. doi:10.1021/acschembio.8b00610
Touati A, Ibrahim NA, Tighilt L, Idres T. Anti-QS Strategies Against Pseudomonas aeruginosa Infections. Microorg. 2025;13(8). doi:10.3390/microorganisms13081838
Falcon CY, Abdelkarim S, Falcon PA, Hirschberg CS, Cugini C. The effect of cinnamon and ginger essential oils against Enterococcus faecalis biofilm: An in vitro feasibility study. Endodontology. 2022;34(4):229-35. doi:10.4103/endo.endo_19_22
Millán YA, Silva RMM, Martínez YP. Use of irrigating substances of natural origin in Endodontics. Salud, Ciencia y Tecnología-Serie de Conferencias [Internet]. 2023 [citado 2 de abril de 2026];2:352. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=9872065
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