Cystatin c as a predictive marker of preeclampsia
DOI:
https://doi.org/10.62305/biosana.v6i4.1176Keywords:
preeclampsia; cystatin c; biomarkers; pregnancy; predictionAbstract
Preeclampsia occurs after 20 weeks of gestation and affects between 3% and 10% of all pregnancies; it manifests primarily through hypertension, proteinuria, and edema (mainly around the ankles). It is associated with various predisposing factors, such as obesity, being overweight, type 1 and type 2 diabetes, arterial hypertension, autoimmune disorders, and renal disease, among others. Various biomarkers are used for diagnosis; however, these are generally considered indicators of severity rather than predictors of the onset of preeclampsia. Conversely, Cystatin C has emerged as a significant predictive biomarker for preeclampsia. Objective: To evaluate the use of Cystatin C as a predictive marker for preeclampsia. Methodology: An observational, descriptive, cross-sectional study was conducted involving 30 patients aged 18 to 38 in their first or second trimester of pregnancy who presented with relevant risk factors, as determined by a survey. Urine and serum analyses were performed, and Cystatin C levels were quantified using immunoturbidimetric assays; results showed a progressive increase correlating with the progression of pregnancy in 90% of the patients. It is concluded that Cystatin C can be considered a predictive marker for preeclampsia, in contrast to other associated biomarkers.
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