Kidney function and complications in patients with type 2 diabetes mellitus treated at the Jipijapa day hospital of the Ecuadorian institute of social security, January to July 2023
DOI:
https://doi.org/10.62305/biosana.v4i2.126Keywords:
Diagnosis; diabetic kidney disease; hyperglycemia; renal profile; renal prognosisAbstract
Type 2 diabetes mellitus is a pathology of heterogeneous etiology with an estimated population of 439 million worldwide by 2030. This disease has been related to microvascular complications, especially diabetic kidney disease, being the main cause of premature mortality. It is essential to diagnose patients who are more sensitive to developing kidney complications for better control of the disease process. The objective was to establish the relationship between kidney function and complications in patients with type 2 diabetes mellitus in the city of Jipijapa, January-July 2023. An observational, cross-sectional and retrospective study was carried out. Rigorous ethical considerations were complied with. Renal function test results (urine creatinine and microalbuminuria) were recorded in 1657 patients with diabetes during the period. Creatinine concentrations were found to be altered in 1.5% of men and 2.4% of women, while 6.2% of patients had elevated microalbuminuria. The renal complications identified in patients with abnormal renal function tests were acute kidney injury (63.1%), diabetic nephropathy with microalbuminuria (22.3%) and chronic kidney disease (14.6%), with an association found between the study variables. These results allow us to conclude that diabetes and its complications continue to be a health problem in Jipijapa and more preventive actions are needed, and a comprehensive therapeutic and clinical approach to these patients.
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References
Ortega Rodríguez DA, Castillo Batista M, García Orozco L. Diabetes mellitus en edades pediátricas. Riesgos a largo plazo. RECIMUNDO. 2022; 6(2):186–192. Disponible en: https://recimundo.com/index.php/es/article/view/1557
Organización Mundial de la Salud (OMS). Diabetes. 2018. Disponible en: https://www.paho.org/es/temas/diabetes
Organización Panamericana de la Salud. Panorama de la diabetes en la Región de las Américas. Washington, D.C.: OPS; 2023. Disponible en: https://doi.org/10.37774/9789275326336.
Organización Mundial de la Salud. Report of expert and stakeholder consultations on the WHO Global Diabetes Compact. Ginebra: OMS; 2021. Disponible en: https://apps.who.int/iris/handle/10665/340322
Instituto Nacional de Estadística y Censos (INEC). Estadísticas Vitales Registro Estadístico de Defunciones. 2022. Disponible en: https://www.ecuadorencifras.gob.ec/documentos/web- inec/Poblacion_y_Demografia/Defunciones_Generales_2021/Principales_resultados_EDG_2021_v2.pdf
Ministerio de Salud Pública. Encuesta Nacional de Salud y Nutrición – ENSANUT. Ecuador. 2018. Disponible en: https://www.salud.gob.ec/encuesta-nacional-de-salud-y-nutricion-ensanut/
National Institute of Diabetes and Digestive and Kidney Diseases. United States Renal Data System. National Institute of Diabetes and Digestive and Kidney Diseases; 2018. Disponible en: https://www.usrds.org/2018/view/Default.aspx
Vélez-Victoria J. Situación actual de la enfermedad renal en Latinoamérica y los desafíos para el cirujano vascular. Rev Mex Angiol. 2023; 51(1): 1-3. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2696-130X2023000100001&lng=es. https://doi.org/10.24875/rma.23000001.
Treacy O, Brown NN, Dimeski G. Biochemical evaluation of kidney disease. Transl Androl Urol. 2019; 8(2): S214–223. Disponible en: https://tau.amegroups.org/article/view/21823/html
American Diabetes Association. Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes—2021. Diabetes Care 2021;44(suppl 1): S15-S33. Disponible en: https://care.diabetesjournals. org/content/44/Supplement_1/S15.
Palacio M, Rodas M, Ullaguari A, Prado A, Zapata J, Lucero D, Chacín M, Bermúdez V. Factores asociados a microalbuminuria y enfermedad renal crónica en pacientes diabéticos que acuden al Hospital Básico de Paute, Ecuador. Revista Latinoamericana de Hipertensión. 2020. 15(1): 76-79. DOI: https://doi.org/10.5281/zenodo.4074256
Navas-Atiaja MI, Moina Veloz AP. Microalbuminuria como indicador de daño renal en pacientes con diabetes mellitus tipo 2. Salud, Ciencia y Tecnología. 2023; 3: 485. DOI: https://doi.org/10.56294/saludcyt2023485.
Pavón-Rojas AJ, Escalona-González SO, Cisnero-Reyes L, González-Milán ZC. Microalbuminuria: método de detección precoz de enfermedad renal crónica en diabéticos. SPIMED. 2020; 1(2): e15. Disponible en: https://revspimed.sld.cu/index.php/spimed/article/view/15
Rico Fontalvo J, Vázquez Jiménez LC, Rodríguez Yánez T, Daza Arnedo R, Raad Sarabia M, Montejo Hernández JD, Lopera Vargas M, Jiménez Quintero J. Enfermedad renal diabética: puesta al día. Anales de la Facultad de Ciencias Médicas. 2022; 55(3):86-98. Disponible en: https://revistascientificas.una.py/index.php/RP/article/view/2961
An N, Wu BT, Yang YW, Huang ZH, Feng JF. Re-understanding and focusing on normoalbuminuric diabetic kidney disease. Front Endocrinol. 2022; 13:1077929. doi: 10.3389/fendo.2022.1077929. PMID: 36531487; PMCID: PMC9757068.
Penno G, Solini A, Orsi E, Bonora E, Fondelli C, Trevisan R, Et al. Renal Insufficiency and Cardiovascular Events (RIACE) Study Group. Non-albuminuric renal impairment is a strong predictor of mortality in individuals with type 2 diabetes: The Renal Insufficiency and Cardiovascular Events (RIACE) Italian multicentre study. Diabetologia. 2018; 61(11):2277-2289. doi: 10.1007/s00125-018-4691-2. PMID: 30032426.
Mansoor G, Tahir M, Maqbool T, Abbasi SQ, Hadi F, Shakoori TA, Akhtar S, Rafiq M, Ashraf M, Ullah Increased Expression of Circulating Stress Markers, Inflammatory Cytokines and Decreased Antioxidant Level in Diabetic Nephropathy. Medicina. 2022; 58(11):1604. doi: 10.3390/medicina58111604. PMID: 36363561; PMCID: PMC9694611.
Ali MK, Pearson-Stuttard J, Selvin E, Gregg EW. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia. 2022; 65(1):3-13. doi: 10.1007/s00125-021-05585-2. PMID: 34837505; PMCID: PMC8660730.
Batista Garcet C, Batista Garcet Y, Jiménez Jiménez C, Rodríguez Pincay R. Perfil renal como ayuda al diagnóstico en habitantes de la parroquia La América del cantón Jipijapa: perfil renal como ayuda al diagnóstico. UNESUM-Ciencias. 2020; 4(3):141-156. Disponible en: https://revistas.unesum.edu.ec/index.php/unesumciencias/article/view/206.
Asamblea Nacional del Ecuador. Ley Orgánica de Protección de Datos Personales. 2021. Disponible en: https://www.telecomunicaciones.gob.ec/wp-content/uploads/2021/06/Ley-Organica-de-Datos- Personales.pdf
Ministerio de Salud Pública del Ecuador. Manual: Gestión interna de los residuos y desechos generados en los establecimientos de salud. Quito. 2019. Disponible en: https://aplicaciones.msp.gob.ec/salud/archivosdigitales/documentosDirecciones/dnn/archivos/AC00036- 2019.pdf
National Institute of Diabetes and Digestive and Kidney Diseases. 2023. Disponible en: https://www.niddk.nih.gov/health-information/informacion-de-la-salud/diabetes/informacion-general/factores-riesgo-tipo-2
Nanayakkara N, Curtis AJ, Heritier S, Gadowski AM, Pavkov ME, Kenealy T, et al. Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses. Diabetologia. 2021; 64(2):275-287. doi: 10.1007/s00125-020-05319-w. PMID: 33313987; PMCID: PMC7801294.
Thipsawat S. Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature. Diab Vasc Dis Res. 2021; 18(6):14791641211058856. doi: 10.1177/14791641211058856. PMID: 34791910; PMCID: PMC8606936.
Hoogeveen EK. La epidemiología de la enfermedad renal diabética. Riñón y Diálisis. 2022; 2(3): 433-442. https://doi.org/10.3390/kidneydial2030038
Nugnes M, Baldassarre M, Ribichini D, Tedesco D, Capelli I, Vetrano D, et al. Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus. Int J Mol Sci. 2024; 25(6):3168. doi: 10.3390/ijms25063168. PMID: 38542146; PMCID: PMC10970212.
Writing Group for the CKD Prognosis Consortium; Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, et al. Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis. JAMA. 2023; 330(13):1266-1277. doi: 10.1001/jama.2023.17002. PMID: 37787795; PMCID: PMC10548311.
Wan KS, Hairi NN, Mustapha F, Mohd Yusoff MF, Mat Rifin H, Ismail M, Moy FM, Ahmad NA. Prevalence of diabetic kidney disease and the associated factors among patients with type 2 diabetes in a multi-ethnic Asian country. Sci Rep. 2024;14(1):7074. doi: 10.1038/s41598-024-57723-6. PMID: 38528132; PMCID: PMC10963363.
Shojima N, Yamauchi T. Progress in genetics of type 2 diabetes and diabetic complications. J Diabetes Investig. 2023;14(4):503-515. doi: 10.1111/jdi.13970. PMID: 36639962; PMCID: PMC10034958.
Mahemuti N, Zou J, Liu C, Xiao Z, Liang F, Yang X. Urinary Albumin-to-Creatinine Ratio in Normal Range, Cardiovascular Health, and All-Cause Mortality. JAMA Netw Open. 2023; 6(12): e2348333. doi: 10.1001/jamanetworkopen.2023.48333. PMID: 38113044; PMCID: PMC10731498
Iheanacho CO, Akhumi TF, Eze UIH, Ojieabu WA. Prevalence and predictors of type 2 diabetes complications: a single centre observation. Afr Health Sci. 2023; 23(3):308-317. doi: 10.4314/ahs.v23i3.37. PMID: 38357114; PMCID: PMC10862620.
Márquez A, Cabanes G, Ramos Y, Castillo G, Fariñas Z, Granado R. Microalbuminuria en pacientes con diabetes tipo 2 y retinopatía diabética. Acta Méd Centro. 2022; 16(1): 24-33. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2709-79272022000100024&lng=es.
Palacio M, Rodas M, Ullaguari A, Prado A, Zapata J, Lucero D, et al. Factores asociados a microalbuminuria y enfermedad renal crónica en pacientes diabéticos que acuden al Hospital Básico de Paute, Ecuador. Revista Latinoamericana de Hipertensión. 2020; 15 (1): 76-79. DOI: https://doi.org/10.5281/zenodo.4074256
Yu SM, Bonventre JV. Acute Kidney Injury and Progression of Diabetic Kidney Disease. Adv Chronic Kidney Dis. 2018; 25(2):166-180. doi: 10.1053/j.ackd.2017.12.005. PMID: 29580581; PMCID: PMC5898826.
Taslamacioglu Duman T, Ozkul FN, Balci B. Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus? Diagnostics (Basel). 2023; 13(12):2063. doi: 10.3390/diagnostics13122063. PMID: 37370958; PMCID: PMC10297511.
Fiorentino M, Grandaliano G, Gesualdo L, Castellano G. Acute Kidney Injury to Chronic Kidney Disease Transition. Contrib Nephrol. 2018; 193:45-54. doi: 10.1159/000484962. PMID: 29393158.
Kaur A, Sharma GS, Kumbala DR. Acute kidney injury in diabetic patients: A narrative review. Medicine (Baltimore). 2023; 102(21): e33888. doi: 10.1097/MD.0000000000033888. PMID: 37233407; PMCID: PMC10219694.
Reddy Mallimala P, Shah K, Mirchandani M, Sharma K. Determinants and Stratification of Microvascular Complications of Type 2 Diabetes Mellitus. Cureus. 2023;15(8):e44348. doi: 10.7759/cureus.44348. PMID: 37779807; PMCID: PMC10539158.
Ogi M, Seto T, Wakabayashi Y. A comparison of the utility of the urine dipstick and urine protein-to-creatinine ratio for predicting microalbuminuria in patients with non-diabetic lifestyle-related diseases -a comparison with diabetes. BMC Nephrol. 2022; 23(1):377. doi: 10.1186/s12882-022-02974-6. PMID: 36434544; PMCID: PMC9700904.
Bueno Junior CR, Bano A, Tang Y, Sun X, Abate A, Hall E, et al. Rapid kidney function decline and increased risk of heart failure in patients with type 2 diabetes: findings from the ACCORD cohort: Rapid kidney function decline and heart failure in T2D. Cardiovasc Diabetol. 2023;22(1):131. doi: 10.1186/s12933-023-01869-6. PMID: 37365586; PMCID: PMC10291814.
Tao J, Sang D, Zhen L, Zhang X, Li Y, Wang G, Chen S, Wu S, Zhang W. Elevated urine albumin-to-creatinine ratio increases the risk of new-onset heart failure in patients with type 2 diabetes. Cardiovasc Diabetol. 2023;22(1):70. doi: 10.1186/s12933-023-01796-6. PMID: 36966320; PMCID: PMC10040119.
Mohammed O, Alemayehu E, Bisetegn H, Debash H, Gedefie A, Ebrahim H, Tilahun M, Fiseha T. Prevalence of Microalbuminuria Among Diabetes Patients in Africa: A Systematic Review and Meta-Analysis. Diabetes Metab Syndr Obes. 2023; 16:2089-2103. doi: 10.2147/DMSO.S409483. PMID: 37457109; PMCID: PMC10349577.
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