Use of cetrizine in androgenetic alopecia

Abstract

When treating allergies, which could be investigated in the context of androgenetic alopecia with the aim of having evaluated its efficacy and safety as an alternative treatment that focused on determining whether cetrizine can improve the symptoms or its progression, possibly by means of modulation of the inflammatory response associated with this condition. We sought to obtain results that expanded the therapeutic options available for patients affected by this common form of hair loss. Cetirizine, through its use in the treatment of allergies, has emerged as a complementary treatment for androgenic alopecia, a form of hair loss characterized by a defined pattern of baldness in men and women. The relationship between cetirizine and androgenic alopecia has been based on its anti-inflammatory properties and its ability to modulate the immune response, which can influence the hair growth cycle. The effect of cetirizine on the inhibition of histamine, an inflammatory mediator that has also played a role in regulating the hair follicular cycle. It will be noted that cetirizine may help prevent the miniaturization of hair follicles, a key process in androgenic alopecia, by reducing local inflammation and modulating immune activity in the scalp. The use of antihistamines in dermatology has been frequent, their uses are broad and for various skin pathologies, therefore it is of interest in the field of dermatology to know the advances, frequent uses, and novelties of this group of drugs for updated clinical practice. . , the use of Cetirizine to treat alopecia, effectiveness has been demonstrated in androgenetic alopecia, frontal fibrosing alopecia, lichen planus pilaris, these being considered the same entity, alopecia areata, therefore this systematic review is carried out to obtain the most important findings in the scientific community and use in clinical practice. Since it is a well-tolerated antihistamine with an anti-inflammatory effect, it reduces PGD2 that inhibits hair growth and increases PGE2 that promotes it. Cetirizine increases PGE, inhibits PGD2 and reduces inflammatory cell infiltration making it a potential safe treatment for AGA. Cetirizine has anti-inflammatory properties and anti-allergic properties so it has fewer side effects than minoxidil. None of the patients reported a specific side effect after the application of Cetirizine