Importancia de la leche materna y la alimentación temprana en el desarrollo y la salud de la microbiota intestinal
DOI:
https://doi.org/10.62305/biosana.v5i3.635Palabras clave:
leche materna; microbiota intestinal; alimentación temprana; sistema inmunológico; prebióticos/probióticosResumen
La leche materna es considerada como el alimento ideal durante los primeros meses de vida debido a su papel fundamental en el desarrollo integral del lactante. Su composición única combina nutrientes esenciales, oligosacáridos, compuestos bioactivos y microorganismos vivos, que no solo satisfacen las necesidades nutricionales del bebé, sino que también desempeñan un rol decisivo en el establecimiento y la maduración de la microbiota intestinal. Este artículo tiene como propósito compilar y examinar críticamente la evidencia científica existente acerca del papel de la microbiota intestinal y sus funciones claves en la digestión, la protección contra patógenos y la modulación del sistema inmunológico. Estos mecanismos contribuyen a la prevención de infecciones y a la reducción del riesgo de enfermedades crónicas como alergias, obesidad y diabetes tipo 1. En este contexto, la leche materna se posiciona como un factor esencial no solo para la nutrición temprana, sino también para la programación inmunológica y el desarrollo de una microbiota intestinal saludable, con efectos que pueden extenderse a lo largo de toda la vida.
Descargas
Citas
Villares J, Collado M, Arqué E, Trabazo M, Pipaon M, Aznar L. Los primeros mil días: una oportunidad para reducir la carga de las enfermedades no transmisibles. Nutr Hosp [Internet]. 2019;36(1):218–32. Available from: https://scielo.isciii.es/pdf/nh/v36n1/1699-5198-nh-36-01-00218.pdf
Guo S, Huang K, Liu R, Sun J, Yin C. Regulation of Gut Microbiota through Breast Milk Feeding Benefits Language and Cognitive Development of Preterm Toddlers. Microorganisms [Internet]. 2023;11(4):1–9. Available from: https://www.mdpi.com/2076-2607/11/4/866
Layuk N, Sinrang AW, Asad S. Early initiation of breastfeeding and gut microbiota of neonates: A literature review. Med Clínica Práctica [Internet]. 2021;4(1):1–12. Available from: https://www.sciencedirect.com/science/article/pii/S2603924921000331
González R, Jiménez I, Gutiérrez P. Human milk microbiota and impact on health. Gac Med Mex [Internet]. 2020;156(Supl 3):S58–66. Available from: https://www.scielo.org.mx/pdf/gmm/v156s3/0016-3813-gmm-156-Supl3-S58.pdf
Minchala R, Ramírez A, Caizaguano M, Altamirano L, Andrade C, Sarmiento M. La lactancia materna como alternativa para la prevención de enfermedades materno-infantiles: Revisión sistemática. Arch Venez Farmacol y Ter [Internet]. 2020;39(8):941–7. Available from: https://www.redalyc.org/journal/559/55969796017/html/
Merino J, Taracena S, Díaz E, Rodríguez F. Microbiota intestinal: el órgano olvidado. Acta Médica Grup Ángeles [Internet]. 2021;19(1):92–100. Available from: https://www.scielo.org.mx/pdf/amga/v19n1/1870-7203-amga-19-01-92.pdf
O’Sullivan A, Farver M, Smilowitz JT. The Influence of early infant-feeding practices on the intestinal microbiome and body composition in infants. Nutr Metab Insights [Internet]. 2019;8(1):1–9. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4686345/pdf/nmi-suppl.1-2015-001.pdf
Davis E, Castagna V, Sela D, Hillard M, Lindberg S, Mantis NJ, et al. Gut microbiome and breast-feeding: Implications for early immune development. J Allergy Clin Immunol [Internet]. 2022;150(3):523–34. Available from: https://www.jacionline.org/article/S0091-6749(22)00992-7/pdf
Inchingolo F, Inchingolo AM, Latini G, Ferrante L, de Ruvo E, Campanelli M, et al. Difference in the Intestinal Microbiota between Breastfeed Infants and Infants Fed with Artificial Milk: A Systematic Review. Pathogens [Internet]. 2024;13(7):1–15. Available from: https://www.mdpi.com/2076-0817/13/7/533
Ma J, Li Z, Zhang W, Zhang C, Zhang Y, Mei H, et al. Comparison of gut microbiota in exclusively breast-fed and formula-fed babies: a study of 91 term infants. Sci Rep [Internet]. 2020;10(1):1–11. Available from: https://doi.org/10.1038/s41598-020-72635-x
Lok K, Teng J, Fong J, Peng Y, Fan HSL, Ma Y, et al. Influence of Feeding Practices on Intestinal Microbiota Composition in Healthy Chinese Infants: A Prospective Cohort Study. J Pediatr Heal Care [Internet]. 2024;1(1):1–12. Available from: https://www.sciencedirect.com/science/article/pii/S0891524524001706
Fehr K, Moossavi S, Sbihi H, Boutin RCT, Bode L, Robertson B, et al. Breastmilk Feeding Practices Are Associated with the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: the CHILD Cohort Study. Cell Host Microbe [Internet]. 2020;28(2):285-297.e4. Available from: https://pdf.sciencedirectassets.com/273614/1-s2.0-S1931312819X00098/1-s2.0-S1931312820303504/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEMj%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJIMEYCIQDLuVL87dPULvkL%2FIk91Q6WWO81SPxQiUh6uFln4R2QiAIhANrIUg6RSJ
Munitis P, Colombo V, Munitis G, Munitis Me, del Pilar M. Guidelines for being a foster care home, report of an experience. Arch Argent Pediatr [Internet]. 2022;120(2):140–4. Available from: https://www.sap.org.ar/docs/publicaciones/archivosarg/2022/v120n1a09.pdf
Ye Y, Yang L, Jiang P-P, Sangild PT, Hui Y, Nielsen DS, et al. Metabolomics reveals changes in levels of fecal branched chain amino acids and organic acids in very preterm infants fed human milk fortified with bovine colostrum. Clin Nutr [Internet]. 2024 Dec;43(12):405–14. Available from: https://pubmed.ncbi.nlm.nih.gov/39581179/
Hiraku A, Nakata S, Murata M, Xu C, Mutoh N, Arai S, et al. Early Probiotic Supplementation of Healthy Term Infants with Bifidobacterium longum subsp. infantis M-63 Is Safe and Leads to the Development of Bifidobacterium-Predominant Gut Microbiota: A Double-Blind, Placebo-Controlled Trial. Nutrients [Internet]. 2023 Mar;15(6):1–19. Available from: https://pubmed.ncbi.nlm.nih.gov/36986131/
Romo J, Arsenault A, Laforce S, Bliss J, Kumamoto C. Minimal Effects of Medium-Chain Triglyceride Supplementation on the Intestinal Microbiome Composition of Premature Infants: A Single-Center Pilot Study. Nutrients [Internet]. 2022 May;14(10):1–11. Available from: https://pubmed.ncbi.nlm.nih.gov/35631300/
Henrick B, Rodriguez L, Lakshmikanth T, Pou C, Henckel E, Arzoomand A, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell [Internet]. 2021 Jul;184(15):3884–98. Available from: https://pubmed.ncbi.nlm.nih.gov/34143954/
Zhu B, Zheng S, Lin K, Xu X, Lv L, Zhao Z, et al. Effects of Infant Formula Supplemented With Prebiotics and OPO on Infancy Fecal Microbiota: A Pilot Randomized Clinical Trial. Front Cell Infect Microbiol [Internet]. 2021;11(1):650407. Available from: https://pubmed.ncbi.nlm.nih.gov/33854983/
Kok C, Brabec B, Chichlowski M, Harris CL, Moore N, Wampler JL, et al. Stool microbiome, pH and short/branched chain fatty acids in infants receiving extensively hydrolyzed formula, amino acid formula, or human milk through two months of age. BMC Microbiol [Internet]. 2020 Nov;20(1):337. Available from: https://pubmed.ncbi.nlm.nih.gov/33167908/
Grzywacz K, Butcher J, Li J, Barrington K, Mohamed I, Stintzi A. Bovine Lactoferrin Supplementation Does Not Disrupt Microbiota Development in Preterm Infants Receiving Probiotics. J Pediatr Gastroenterol Nutr [Internet]. 2020 Aug;71(2):216–22. Available from: https://pubmed.ncbi.nlm.nih.gov/32404742/
Castanet M, Costalos C, Haiden N, Hascoet J-M, Berger B, Sprenger N, et al. Early Effect of Supplemented Infant Formulae on Intestinal Biomarkers and Microbiota: A Randomized Clinical Trial. Nutrients [Internet]. 2020 May;12(5):1–20. Available from: https://pubmed.ncbi.nlm.nih.gov/32443684/
Berger B, Porta N, Foata F, Grathwohl D, Delley M, Moine D, et al. Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics. MBio. 2020 Mar;11(2):1–18.
Son M, Laury ML, Stephenson KB, May T, Hendrixson DT, Koroma AS, et al. The Impact of Milk on Gut Permeability, Fecal 16S rRNA Gene Microbiota Profiling, and Fecal Metabolomics in Children with Moderate Malnutrition in Sierra Leone: A Double-Blind, Randomized Controlled Trial. Am J Clin Nutr [Internet]. 2024 Nov;120(5):1114–24. Available from: https://pubmed.ncbi.nlm.nih.gov/39307188/
Plaza J, Bernal M, Schutte S, Chenoll E, Genovés S, Codoñer F, et al. Effects of Whole-Grain and Sugar Content in Infant Cereals on Gut Microbiota at Weaning: A Randomized Trial. Nutrients [Internet]. 2021 Apr;13(5):1–17. Available from: https://pubmed.ncbi.nlm.nih.gov/33925049/
da Silva V, Smith N, Mullaney J, Wall C, Roy N, McNabb W. Food-breastmilk combinations alter the colonic microbiome of weaning infants: an in silico study. mSystems [Internet]. 2024 Sep;9(9):1–11. Available from: https://pubmed.ncbi.nlm.nih.gov/39191378/
Leong C, Haszard JJ, Lawley B, Otal A, Taylor RW, Szymlek-Gay EA, et al. Mediation Analysis as a Means of Identifying Dietary Components That Differentially Affect the Fecal Microbiota of Infants Weaned by Modified Baby-Led and Traditional Approaches. Appl Environ Microbiol [Internet]. 2019 Sep;84(18):1–14. Available from: https://journals.asm.org/doi/pdf/10.1128/aem.00914-18
Ordiz I, Janssen S, Humphrey G, Ackermann G, Stephenson K, Agapova S, et al. The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months. Am J Clin Nutr [Internet]. 2020 Apr;111(4):884–92. Available from: https://pubmed.ncbi.nlm.nih.gov/32047925/
Calder N, Walsh K, Olupot-Olupot P, Ssenyondo T, Muhindo R, Mpoya A, et al. Modifying gut integrity and microbiome in children with severe acute malnutrition using legume-based feeds (MIMBLE): A pilot trial. Cell reports Med [Internet]. 2021 May;2(5):100280. Available from: https://pubmed.ncbi.nlm.nih.gov/34095882/
Estorninos E, Lawenko RB, Palestroque E, Sprenger N, Benyacoub J, Kortman GAM, et al. Term infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that of human milk-fed infants and improves intestinal immune defense: a randomized controlled trial. Am J Clin Nutr [Internet]. 2022 Jan;115(1):142–53. Available from: https://pubmed.ncbi.nlm.nih.gov/34617558/
Brink L, Mercer K, Piccolo B, Chintapalli S, Elolimy A, Bowlin AK, et al. Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula. Am J Clin Nutr [Internet]. 2020 Jun;111(6):1190–202. Available from: https://pubmed.ncbi.nlm.nih.gov/32330237/
Kamng’ona A, Young R, Arnold CD, Patson N, Jorgensen JM, Kortekangas E, et al. Provision of Lipid-Based Nutrient Supplements to Mothers During Pregnancy and 6 Months Postpartum and to Their Infants from 6 to 18 Months Promotes Infant Gut Microbiota Diversity at 18 Months of Age but Not Microbiota Maturation in a Rural Malawian Setti. J Nutr [Internet]. 2020 Apr;150(4):918–28. Available from: https://pubmed.ncbi.nlm.nih.gov/31909811/
Agapova S, Stephenson K, Divala O, Kaimila Y, Maleta KM, Thakwalakwa C, et al. Additional Common Bean in the Diet of Malawian Children Does Not Affect Linear Growth, but Reduces Intestinal Permeability. J Nutr [Internet]. 2018 Feb;148(2):267–74. Available from: https://pubmed.ncbi.nlm.nih.gov/29490090/
Buonocore G. Microbiota and gut immunity in infants and young children. Glob Pediatr [Internet]. 2024;9(1):1–4. Available from: https://www.sciencedirect.com/science/article/pii/S2667009724000708
Adamczak A, Werblińska A, Jamka M, Walkowiak J. Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health. Biomedicines [Internet]. 2024;12(3):1–19. Available from: https://www.mdpi.com/2227-9059/12/3/490
Tanaka M, Nakayama J. Development of the gut microbiota in infancy and its impact on health in later life. Allergol Int [Internet]. 2019;66(4):515–22. Available from: https://www.sciencedirect.com/science/article/pii/S1323893017301119
Kaczmarczyk M, Löber U, Adamek K, Węgrzyn D, Skonieczna-Żydecka K, Malinowski D, et al. The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life. J Transl Med [Internet]. 2021;19(1):1–26. Available from: https://doi.org/10.1186/s12967-021-02839-w
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2025 Revista Científica de Salud BIOSANA

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.




