Uso de ácido acetilsalicílico (AAS) en la producción porcina
Palabras clave:
Salud animal, Rendimiento productive, Terapia farmacológica, Bienestar porcinoResumen
La producción porcina desempeña un papel fundamental en la agricultura mundial, enfrentando desafíos en salud y bienestar animal. El ácido acetilsalicílico (AAS) surge como una herramienta prometedora para mejorar el crecimiento, reducir el estrés y manejar enfermedades. Este estudio tuvo como objetivo analizar el uso integral de los EAA en cerdos para fomentar prácticas sostenibles y productivas. Se llevó a cabo una revisión bibliográfica cualitativa utilizando la metodología PRISMA, y enfocándose en estudios desde 1970 a 2024. Los datos se recopilaron mediante una búsqueda sistemática en bases académicas y bibliografías clave, evaluando vías de administración, propósitos terapéuticos y efectos en la producción porcina. De 14 estudios seleccionados, los resultados mostraron que el AAS mejora la salud intestinal y el crecimiento en lechones destetados, aunque presenta riesgos de efectos adversos gastrointestinales. En cerdos en crecimiento, su uso como coadyuvante en enfermedades respiratorias fue destacado, mientras que, en la etapa de engorde, su manejo cuidadoso fue esencial para evitar lesiones gástricas. Se concluye que el AAS contribuye significativamente al bienestar y rendimiento productivo de los cerdos, siempre que su uso se ajuste a dosis y vías de administración adecuadas para maximizar beneficios y minimizar riesgos.
Palabras claves: Salud animal, Rendimiento productive, Terapia farmacológica, Bienestar porcino.
ABSTRACT
Swine production plays a key role in global agriculture and faces animal health and welfare challenges. Acetylsalicylic acid (ASA) emerges as a promising tool to improve growth, reduce stress and control disease. This study aimed to analyze the comprehensive use of ASA in pigs to promote sustainable and productive practices. A qualitative literature review was conducted using PRISMA methodology, focusing on studies conducted between 1970 and 2024. Data were collected through a systematic search of academic databases and key bibliographies, evaluating routes of administration, therapeutic purposes, and effects on swine production. From 14 selected studies, the results showed that ASA improves intestinal health and growth in weaned piglets, although it presents risks of gastrointestinal adverse effects. In growing pigs, its use as an adjuvant in respiratory diseases was highlighted, while, in the fattening stage, its careful management was essential to avoid gastric lesions. It is concluded that AAS contributes significantly to the welfare and productive performance of pigs, provided that its use is adjusted to adequate doses and routes of administration to maximize benefits and minimize risks.
Keywords: Animal health, Productive performance, Pharmacological therapy, Swine welfare.
Información del manuscrito:
Fecha de recepción: 05 de septiembre de 2024.
Fecha de aceptación: 11 de diciembre de 2024.
Fecha de publicación: 20 de enero de 2025.
Descargas
Citas
Amenu, K., McIntyre, K. M., Moje, N., Knight-Jones, T., Rushton, J. y Grace, D. (2023). Approaches for disease prioritization and decision-making in animal health, 2000–2021: A structured scoping review. Frontiers in Veterinary Science, 10, 1231711. https://doi.org/10.3389/fvets.2023.1231711
Azarian, M., Yu, H., Shiferaw, A. T. y Stevik, T. K. (2023). Do We Perform Systematic Literature Review Right? A Scientific Mapping and Methodological Assessment. Logistics, 7(4), 89. https://doi.org/10.3390/logistics7040089
Barry, E. S., Merkebu, J. y Varpio, L. (2022). State-of-the-art literature review methodology: A six-step approach for knowledge synthesis. Perspectives on Medical Education, 11(5), 1–8. https://doi.org/10.1007/S40037-022-00725-9
Beauchemin, É., Côté, L., Drolet, M. y Williams, B. (2022). Conceptualising Ethical Issues in the Conduct of Research: Results from a Critical and Systematic Literature Review. Journal of Academic Ethics, 20(3), Article 3. https://doi.org/10.1007/s10805-021-09411-7
Camp, J., Manzanilla, E. G., Solà, D., Muns, R., Gasa, J., Clear, O. y Calderón Díaz, J. A. (2020). Predicting Productive Performance in Grow-Finisher Pigs Using Birth and Weaning Body Weight. Animals, 10(6), 1017. https://doi.org/10.3390/ani10061017
Cao, S., Thanapal, P. y Kim, H. (2022). Effects of salicylic acid on growth performance, fecal score, blood profile, and nutrient digestibility in weaned pigs. (No. 4). 102(4), Article 4. https://doi.org/10.1139/cjas-2022-0077
Charlier, J., Barkema, H. W., Becher, P., De Benedictis, P., Hansson, I., Hennig-Pauka, I., La Ragione, R., Larsen, L. E., Madoroba, E., Maes, D., Marín, C. M., Mutinelli, F., Nisbet, A. J., Podgórska, K., Vercruysse, J., Vitale, F., Williams, D. J. L. y Zadoks, R. N. (2022). Disease control tools to secure animal and public health in a densely populated world. The Lancet Planetary Health, 6(10), e812–e824. https://doi.org/10.1016/S2542-5196(22)00147-4
Clopath, P. (1980). The effect of acetylsalicylic acid (ASA) on the development of atherosclerotic lesions in miniature swine (No. 4). 61(4), Article 4. https://pubmed.ncbi.nlm.nih.gov/7426393
Di Bella, S., Luzzati, R., Principe, L., Zerbato, V., Meroni, E., Giuffrè, M., Crocè, L. S., Merlo, M., Perotto, M., Dolso, E., Maurel, C., Lovecchio, A., Dal Bo, E., Lagatolla, C., Marini, B., Ippodrino, R. y Sanson, G. (2022). Aspirin and Infection: A Narrative Review. Biomedicines, 10(2), 263. https://doi.org/10.3390/biomedicines10020263
Düpjan, S. y Dawkins, M. S. (2022). Animal Welfare and Resistance to Disease: Interaction of Affective States and the Immune System. Frontiers in Veterinary Science, 9, 929805. https://doi.org/10.3389/fvets.2022.929805
Fausnacht, D., Kroscher, K., McMillan, R., Martello, L., Baumgard, L. H., Selsby, J., Hulver, M. y Rhoads, R. (2021). Heat Stress Reduces Metabolic Rate While Increasing Respiratory Exchange Ratio in Growing Pigs. Animals, 11(1), Article 1. https://doi.org/10.3390/ani11010215
Fijałkowski, Ł., Skubiszewska, M., Grześk, G., Koech, F. y Nowaczyk, A. (2022). Acetylsalicylic Acid–Primus Inter Pares in Pharmacology. Molecules, 27(23), Article 23. https://doi.org/10.3390/molecules27238412
Fourie, J., Shah, M., Vallejo, J., Cheng, J., Ayyoub, A., Liu, J., Hudson, R., Sridhara, R., Ison, G., Amiri-Kordestani, L., Tang, S., Gwise, T., Rahman, A., Pazdur, R. y Theoret, M. R. (2022). Improving Dose-Optimization Processes Used in Oncology Drug Development to Minimize Toxicity and Maximize Benefit to Patients. Journal of Clinical Oncology, 40(30), 3489–3500. https://doi.org/10.1200/JCO.22.00371
Fugazzola, M. C., Wever, K. E., Van De Lest, C., De Grauw, J. y Salvatori, D. (2022). Reporting of anaesthesia and pain management in preclinical large animal models of articular cartilage repair—A long way to go. Osteoarthritis and Cartilage Open, 4(2), 100261. https://doi.org/10.1016/j.ocarto.2022.100261
Ganann, R., Ciliska, D. y Thomas, H. (2010). Expediting systematic reviews: Methods and implications of rapid reviews. Implementation Science, 5(1), 56. https://doi.org/10.1186/1748-5908-5-56
Ghidini, S., Scali, F., Romeo, C., Guadagno, F., Maisano, A. M., De Luca, S., Varrà, M. O., Conter, M., Ianieri, A., Zanardi, E. y Alborali, G. L. (2023). A Preliminary Study on the Relationship between Gastric Lesions and Anti-Inflammatory Drug Usage in Heavy Pigs. Veterinary Sciences, 10(9), 551. https://doi.org/10.3390/vetsci10090551
Guevara, R., Ko, H.-L., Stuardo, L. y Manteca, X. (2024). 23—Global developments in pig welfare: From legislation to market-driven change. 517–535. https://doi.org/10.1016/B978-0-323-85676-8.00005-5
Heringer, S., Kabelitz, L., Kramer, M., Nikoubashman, O., Brockmann, M. A., Kirschner, S. y Wiesmann, M. (2019). Platelet function testing in pigs using the Multiplate® Analyzer. PLOS ONE, 14(8), Article 8. https://doi.org/10.1371/journal.pone.0222010
Janssens, A., Gwinn, M., Brockman, J., Powell, K. y Goodman, M. (2020). Novel citation-based search method for scientific literature: A validation study. BMC Medical Research Methodology, 20(1), 25. https://doi.org/10.1186/s12874-020-0907-5
Kim, J., Mullan, B., Black, J., Hewitt, R., Van, R. y Pluske, J. (2016). Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E. coli. Journal of Animal Science and Biotechnology, 7(1), Article 1. https://doi.org/10.1186/s40104-016-0118-4
Kim, S., Gormley, A., Jang, K. y Duarte, M. (2024). — Invited Review — Current status of global pig production: An overview and research trends. Animal Bioscience, 37(4), Article 4. https://doi.org/10.5713/ab.23.0367
Mengesha, A. (2021). A Review on Veterinary Drug Management, Handling, Utilization and Its Resistance Side Effects. Austin Journal of Veterinary Science & Animal Husbandry, 8(2). https://doi.org/10.26420/austinjvetscianimhusb.2021.1079
Monticelli, M., Liguori, L., Allocca, M., Bosso, A., Andreotti, G., Lukas, J., Monti, M. C., Morretta, E., Cubellis, M. V. y Hay Mele, B. (2022). Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones. International Journal of Molecular Sciences, 23(9), 5105. https://doi.org/10.3390/ijms23095105
Muhizi, S., Cho, S., Palanisamy, T. y Kim, I. H. (2022). Effect of dietary salicylic acid supplementation on performance and blood metabolites of sows and their litters. Journal of Animal Science and Technology, 64(4), Article 4. https://doi.org/10.5187/jast.2022.e25
National Cancer Institute. (2020). Nitric Oxide-Releasing Acetylsalicylic Acid Derivative. En Definitions. Qeios. https://doi.org/10.32388/933PBV
Organización para la Cooperación y el Desarrollo Económico [OCDE] & Organización de las Naciones Unidas para la Alimentación y la Agricultura [FAO]. (2021). Perspectivas Agrícolas 2021‑2030. 362. https://doi.org/10.1787/47a9fa44-es
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Alonso-Fernández, S. (2021). Declaración PRISMA 2020: Una guía actualizada para la publicación de revisiones sistemáticas. Revista Española de Cardiología, 74(9), 790–799. https://doi.org/10.1016/j.recesp.2021.06.016
Palus, K. y Całka, J. (2015). The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach. PLOS ONE, 10(11), e0143661. https://doi.org/10.1371/journal.pone.0143661
Racciatti, D. S., Wiemeyer, G. M., González Gracia, L. A., Blanco, C., Szmelc, A. y Orozco, M. M. (2023). Links between animal welfare and “One Health”: Perception and implementation in Latin America. Frontiers in Animal Science, 4, 1242917. https://doi.org/10.3389/fanim.2023.1242917
Rahman, A., Musleh, D., Nabil, M., Alubaidan, H., Gollapalli, M., Krishnasamy, G., Almoqbil, D., Khan, M., Farooqui, M., Ahmed, M., Ahmed, M. y Mahmud, M. (2022). Assessment of Information Extraction Techniques, Models and Systems. Mathematical Modelling of Engineering Problems, 9(3), Article 3. https://doi.org/10.18280/mmep.090315
Rainsford, R., Stetsko, P., Sirko, S. y Debski, S. (2003). Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: A model for human gastrointestinal disease. 55, 661–668. https://doi.org/10.1211/002235703765344577
Raja, M., Selvakumar, K., Pandian, A., Sundaram, S., Anbukkani, P. y Jayanthi, R. (2022). Profitability and efficiency of pig production in Tamil Nadu. https://doi.org/10.56093/ijans.v92i3.122271
Rauw, W., Rydhmer, L., Kyriazakis, I., Øverland, M., Gilbert, H., Dekkers, J., Hermesch, S., Bouquet, A., Gómez, E., Louveau, I. y Gomez, L. (2020). Prospects for sustainability of pig production in relation to climate change and novel feed resources. Journal of the Science of Food and Agriculture, 100(9), 3575–3586. https://doi.org/10.1002/jsfa.10338
Rodrigues, L. A., Koo, B., Nyachoti, M. y Columbus, D. A. (2022). Formulating Diets for Improved Health Status of Pigs: Current Knowledge and Perspectives. Animals, 12(20), 2877. https://doi.org/10.3390/ani12202877
Rodrigues, M. y Diana, A. (2022). A Systematic Review on the Link between Animal Welfare and Antimicrobial Use in Captive Animals. Animals, 12(8), 1025. https://doi.org/10.3390/ani12081025
Salichs, M., Sabaté, D., Ciervo, O. y Homedes, J. (2011). Comparison of the antipyretic efficacy of ketoprofen, acetylsalicylic acid, and paracetamol, orally administered to swine. Journal of Veterinary Pharmacology and Therapeutics, 35(2), Article 2. https://doi.org/10.1111/j.1365-2885.2011.01314.x
Samama, C., Bonnin, P., Bonneau, M., Pignaud, G., Mazoyer, E., Bailliart, O., Maffrand, J., Viars, P., Caen, J. y Drouet, L. (1992). Comparative Arterial Antithrombotic Activity of Clopidogrel and Acetyl Salicylic Acid in the Pig. 68(05), 500–505. https://doi.org/DOI: 10.1055/s-0038-1646307
Schimmel, D., Schimmel, I., Lutter, K. y Putsche, R. (1975). Effect of acetylsalicylic acid on experimentally induced endotoxin reactions in swine. PMID, 30(6), 951.
Schoos, A., Devreese, M. y Maes, D. G. (2019a). Use of non‐steroidal anti‐inflammatory drugs in porcine health management. Veterinary Record, 185(6), 172–172. https://doi.org/10.1136/vr.105170
Schoos, A., Devreese, M. y Maes, D. G. (2019b). Use of non‐steroidal anti‐inflammatory drugs in porcine health management. Veterinary Record, 185(6), Article 6. https://doi.org/10.1136/vr.105170
Shanchuan, C., Palanisamy, T. y In, H. (2022). Effects of salicylic acid on growth performance, fecal score, blood profile, and nutrient digestibility in weaned pigs. (No. 4). 102(4), Article 4. https://doi.org/10.1139/cjas-2022-0077
Soukka, H., Viinikka, L. y Kääpä, P. (1998). Involvement of Thromboxane A2 and Prostacyclin in the Early Pulmonary Hypertension after Porcine Meconium Aspiration. 44, 838–842. https://doi.org/10.1203/00006450-199812000-00003
Thompson, J., Thorne, S. y Sandhu, G. (2021). Interpretive description: A flexible qualitative methodology for medical education research. Medical Education, 55(3), Article 3. https://doi.org/10.1111/medu.14380
Turnbull, D., Chugh, R. y Luck, J. (2023). Systematic-narrative hybrid literature review: A strategy for integrating a concise methodology into a manuscript. Social Sciences & Humanities Open, 7(1), 100381. https://doi.org/10.1016/j.ssaho.2022.100381
Vane, S. (1998). Differential inhibition of cyclooxygenase isoforms: An explanation of the action of NSAIDs. 4(5), 3–10. https://doi.org/10.1097/00124743-199810001-00002
Vilalta, C., Alcala, T., Lopez, R., Nofrarias, M., Lopez, G., Espin, S., Varela, T. y Fraile, L. (2011). Clinical efficacy of acetylsalicylic acid as an adjunct to antibacterial treatment of porcine respiratory disease complex. Journal of Swine Health and Production, 20(1), Article 1. https://doi.org/10.54846/jshap/706
Xu, Z. R., Kornegay, E. T., Sweet, L. A., Lindemann, M. D., Veit, H. P. y Watkins, B. A. (1990). Effects of feeding aspirin and soybean oil to weanling pigs. Journal of Animal Science, 68(6), Article 6. https://doi.org/10.2527/1990.6861639x
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2025 Revista Científica Multidisciplinaria HEXACIENCIAS. ISSN: 3028-8657

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.




